Discontinuation Study Of Citalopram (Antidepressant) in Depressed Adolescents

• Status: Withdrawn
• Trial end date: 2006-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to evaluate whether it is advantageous for adolescents who have recovered from depression after a 6 to 12 week course of antidepressant treatment to stay on the treatment a further 6 months or is it just as helpful to stop the medication after recovery.

The hypothesis is that adolescents with major depression who recover from the 6 to 12 week trial of citalopram will be less likely to have a recurrence of depression over a 6 month period if continued on the citalopram as compared to those who discontinue the medication.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sunnybrook Health Sciences Centre
• Treatments: Citalopram; Dexetimide

Criteria

Inclusion Criteria:

• Diagnosis of major Depression.

• Age 13-18.

• A score of > 16 on the 17 item Hamilton Depression Scale or a score of > 12 on the 17 items plus a score of >7 on the atypical items.

• Males and females.

• Outpatient at initiation of double blind treatment phase.

• Ability to give informed consent.

Exclusion Criteria:

• Past or current hypomanic or manic episode.

• Currently meets criteria for a Conduct Disorder.

• Current psychotic symptoms.

• Substance dependence in the last 3 months.

• Significant medical condition that would contraindicate the use of an antidepressant.

• Pregnancy

• Past treatment with Citalopram for major depression