Discovery and Validation of Genetic Variants Affecting Microglial Activation in Alzheimer's Disease
Status:
Recruiting
Trial end date:
2026-12-01
Target enrollment:
Participant gender:
Summary
The primary objectives are to validate that a previously identified gene variant influences
the proportion of activated microglia (PAM) and the amount of TSPO binding on PET imaging, to
identify novel loci that influence PAM and TSPO PET, and to understand the functional
consequences of gene variants that drive microglial activation in Alzheimer's disease.