Dissecting the Role of Estradiol in Mediating Gender-specific Anxiolytic and Prosocial Effects of Oxytocin

• Status: Completed
• Trial end date: 2020-01-25
• Target enrollment: 0
• Participant gender: All

Summary

The study aims to examine a behavioral and neural framework for understanding the sex-specific effects of the neuropeptide oxytocin (OXT). Using hormonal, behavioral and neuroimaging readouts, it is planned to explore the interplay of OXT and estradiol as a potential mechanism mediating sexual dimorphic effects.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital, Bonn
• Treatments: Anti-Anxiety Agents; Estradiol; Estradiol 17 beta-cypionate; Estradiol 3-benzoate; Estrogens; Oxytocin; Polyestradiol phosphate

Criteria

Inclusion Criteria:

• right handed

• healthy male & female volunteers

• women will be tested in their follicular phase (Day 0-5)

Exclusion Criteria:

• smoking

• pregnancy

• hormonal contraception

• current psychiatric illness

• current psychiatric medication or psychotherapy

• Study 2: MRI contraindication (e.g. metal in body, claustrophobia)