Distribution of Rubidium-82, Nitrogen-13 Ammonia, and Fluorine-18 Fluorodeoxyglucose in Normal Volunteers
Status:
Completed
Trial end date:
2018-01-19
Target enrollment:
Participant gender:
Summary
Establish the normal distributions of Rb-82, N-13 ammonia, and F-18 FDG (radioactive tracers)
in the heart using PET imaging. These tracers would be eventually used in evaluating the
hearts of patients with heart disease.
Normal healthy volunteers will be carefully screened for this study. Subjects will be given
IV administration of Rb-82 and N-13 to acquire rest/stress imaging. Normal subjects not
excluded by any unexpected abnormality during the Rb-82 or N-13 rest/stress studies will
undergo a glucose loading F-18 FDG imaging protocol, viability protocol using the
hyperinsulinemic euglycemic clamp with simultaneous IV infusions of dextrose and insulin
according to standard procedures in our laboratory.
These same subjects will have a F-18 FDG protocol after following a high fat, protein
permitted, no carbohydrate diet for approximately 30 hours prior to F-18 FDG injection. The
F-18 FDG radiotracer will be given through an IV.