Diuretic Effect of Metolazone Pre-dosing Versus Concurrent Dosing

• Status: Terminated
• Trial end date: 2020-01-10
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to examine whether administering metolazone 60 minutes prior to furosemide increases urine output compared with administering metolazone and furosemide concomitantly. Participants will have equal chance of being assigned to each group.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Maryland; University of Maryland, Baltimore
• Treatments: Diuretics; Furosemide; Metolazone

Criteria

Inclusion Criteria:

• Admission within 48 hours for acute decompensated heart failure with at least one symptom and one sign of volume overload

• Receipt of loop diuretic prior to admission

• Plan to administer furosemide 120 - 160 mg IV bolus twice daily over the next 24 hours with additional diuresis deemed necessary

• If patient is concurrently administered intravenous vasodilator or inotrope, the dose of vasodilator or inotrope must be stable for 6 hours prior to enrollment with a plan to continue the same dose for the 24 hour duration of this study

Exclusion Criteria:

• Metolazone prescribed prior to admission

• Receipt of continuous intravenous infusion of furosemide

• Cirrhosis or end stage renal disease

• Non-English speaking patients