Do Flavors Increase the Addiction Potential of Nicotine?

• Status: Completed
• Trial end date: 2021-08-31
• Target enrollment: 0
• Participant gender: All

Summary

The FDA has concluded that flavors (e.g. menthol) are associated with greater addiction potential in tobacco cigarettes (Gottlieb March 13, 2019). Whether the same is true for e-cigarettes and non-menthol flavors is unclear and our study should help answer this question.

Our major hypothesis is that the pharmacological effect of nicotine to induce addiction will be greater with use of a preferred e-cigarette flavor than with use of a non-preferred flavor. The pharmacological effect will be measured by how much a larger nicotine dose increases addiction potential compared to a smaller dose.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Vermont
• Treatments: Nicotine

Criteria

Inclusion criteria:

• 21 years or older

• comfortable reading and writing English

• own a JUUL brand e-cigarette they have used at least 10 times in the past 30 days

• use JUUL e-cigarettes and JUUL pods with 5% nicotine

• used e-cigarettes on 4+ days a week in the last 30 days

• use or do not use tobacco cigarettes

• do not plan to quit e-cigarettes in the next 30 days

• non-pregnant females verified by pregnancy test

• access to the internet in a location where they could join a videoconference call and legally use their JUUL.

• Reside in VT