Overview

Docetaxel in Treating Older Patients With Metastatic Breast, Lung, or Prostate Cancer

Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Drugs used in chemotherapy, such as docetaxel, use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: This phase II trial is studying how well docetaxel works in treating older patients with metastatic breast, lung, or prostate cancer.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Memorial Sloan Kettering Cancer Center
Collaborator:
National Cancer Institute (NCI)
Treatments:
Docetaxel
Criteria
DISEASE CHARACTERISTICS:

- Histologically proven metastatic breast, lung, or prostate cancer

- Measurable disease

- No untreated CNS metastases

- No symptomatic CNS metastases requiring escalating doses of corticosteroids

- Hormone receptor status:

- Not specified

PATIENT CHARACTERISTICS:

Age

- 65 and over

Sex

- Not specified

Menopausal status

- Not specified

Performance status

- Karnofsky 70-100%

Life expectancy

- Not specified

Hematopoietic

- Absolute neutrophil count at least 1,500/mm^3

- Hemoglobin at least 8.0 g/dL

- Platelet count at least 100,000/mm^3

Hepatic

- Bilirubin normal

- SGOT and/or SGPT no greater than 2.5 times upper limit of normal (ULN) with alkaline
phosphatase no greater than ULN OR

- Alkaline phosphatase no greater than 4 times ULN with SGOT and SGPT no greater than
ULN

Renal

- Not specified

Cardiovascular

- No history of cardiac arrhythmia

- No congestive heart failure

- No myocardial infarction within the past 6 months

Other

- No prior severe hypersensitivity reaction to docetaxel or other drugs containing
polysorbate 80

- No allergy to macrolide antibiotics

- No grade 2 or greater peripheral neuropathy

- No concurrent serious or uncontrolled infection

- Able to read, write, and converse in English

PRIOR CONCURRENT THERAPY:

Biologic therapy

- Not specified

Chemotherapy

- Recovered from prior chemotherapy

Endocrine therapy

- See Disease Characteristics

Radiotherapy

- Recovered from prior radiotherapy

Surgery

- Not specified

Other

- No concurrent CYP3A4-inducing or inhibiting medications or herbal remedies

- No concurrent grapefruit juice

- No concurrent ethanol