Documentation of Efficacy of Intralymphatic Allergen Immunotherapy

• Status: Active, not recruiting
• Trial end date: 2023-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Investigation of the clinical efficacy of 3 intralymphatic injections with grass pollen extract into inguinal lymph nodes on combined symptom-medication scores during grass pollen season in grass pollen allergic patients compared to placebo

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Aarhus University Hospital
• Collaborators: University Hospital, Linkoeping; University of Aarhus

Criteria

Inclusion Criteria:

• moderate-severe grass pollen allergic rhinoconjunctivitis

• positive skin prick test for grass pollen extract

Exclusion Criteria:

• significant mugwort allergy

• previous AIT for grass pollen allergy

• uncontrolled non-allergic upper airways disease

• uncontrolled asthma

• planned depot steroid injections during season

• uncontrolled autoimmune diseases

• active malignancies

• uncontrolled other severe condition, including psychiatric diseases