Does Allopurinol Prolong a Treated, Acute Gout Flare?

• Status: Completed
• Trial end date: 2013-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a double blind placebo controlled study to determine whether starting allopurinol during a treated acute gout attack will have any effect on the duration of the attack.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: 59th Medical Wing; Wilford Hall Medical Center
• Collaborator: United States Air Force
• Treatments: Allopurinol

Criteria

Inclusion Criteria requires both of:

• Crystal proven gout, and

• An acute gout attack within 72 hours of first treatment

Plus one of the following:

• At least 2 gout attacks in past 12 months

• Tophus

• Nephrolithiasis

• 24hr urine uric acid greater than 1000mg

Exclusion Criteria:

• Inability to return for examinations

• Glomerular filtration rate (calculated) less than 50 milliliters per minute

• Allopurinol use in past 6 months

• Ongoing cancer therapy

• Concomitant azathioprine or cyclophosphamide

• Any one of the following liver enzymes greater than 1.25 times the upper limit of normal:

• AST [Aspartate aminotransferase]

• ALT [Alanine aminotransferase]

• alkaline phosphatase

• Pre-gout pain in involved joint of more than 3 on a scale of 1-10

• Neurologic deficit around the involved joint