Does Ascorbic Acid Reduce Sympathoexcitation in CHF?

• Status: Completed
• Trial end date: 2008-04-01
• Target enrollment: 0
• Participant gender: All

Summary

In CHF central sympathetic activity is increased. ROS formation seems to play a role in this process. This study analyzes the effect of vitamin C as an antioxidant on central sympathetic activity in CHF

• Phase: N/A

Details

• Lead Sponsor: Radboud University
• Collaborator: ZonMw: The Netherlands Organisation for Health Research and Development
• Treatments: Ascorbic Acid

Criteria

Inclusion Criteria:

• Heart failure of at least New York Heart Association (NYHA) class II

• Left ventricular ejection fraction (LVEF) <= 40%

• Age 20-80 years

Exclusion Criteria:

• Necessity of short-term PCI, CABG or heart transplantation,

• Chronic disease of the autonomic nervous system,

• diabetes mellitus,

• use of tricyclic antidepressant drugs and/or a-adrenergic receptor antagonists.