Does B Vitamin Supplementation Decrease Homocysteine Concentrations in Newborns

• Status: Completed
• Trial end date: 2003-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether supplementation with folinic acid, a B vitamin, lowers the concentrations of total homocysteine in newborns. Increased homocysteine concentrations are associated with an increased risk of cerebrovascular accidents in adult, children and newborns. These increased concentrations can easily and safely be lowered by folic acid in adults.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Radboud University
• Treatments: Folic Acid; Formyltetrahydrofolates; Leucovorin; Levoleucovorin

Criteria

Inclusion Criteria:

• admitted at our NICU

Exclusion Criteria:

• midline defects

• Extracorporeal membrane oxygenation (ECMO) treatment

• blood transfusion

• overt renal failure