Does Bowel Stimulation Before Loop Ileostomy Closure Reduce Postoperative Ileus?

• Status: Active, not recruiting
• Trial end date: 2022-07-31
• Target enrollment: 0
• Participant gender: All

Summary

Postoperative ileus is the most commonly observed morbidity following ileostomy closure. Studies have previously demonstrated that the defunctionalized bowel of a loop ileostomy undergoes a series of functional and structural changes. It has been hypothesized that these changes may contribute to the development of postoperative ileus, and that stimulating the distal limb of a loop ileostomy prior to closure may functionally prepare the excluded bowel for intestinal transit.

The purpose of the multicenter, randomized controlled trial is to determine the impact of preoperative stimulation of the distal limb of a loop ileostomy on postoperative ileus.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Jewish General Hospital
• Collaborators: Maisonneuve-Rosemont Hospital; Montreal General Hospital; North Shore Hospital, Waitemata District Health Board; North York General Hospital; Rush University Medical Center; St. Mary's General Hospital; St. Paul's Hospital, Canada; Sunnybrook Health Sciences Centre

Criteria

Inclusion Criteria:

• All patients will have undergone an anterior or low-anterior resection for malignant or benign disease with a protective loop ileostomy by a board-certified colorectal surgeon or surgical oncologist at one of the involved sites.

Exclusion Criteria:

• Patients with a protective ileostomy following colonic resection for Crohn's disease will be excluded from entering the study, as well as patients from whom clear and informed consent cannot be obtained.