Does Caffeine Reduce Rosuvastatin-Induced Protection Against Ischemia-Reperfusion Injury?

• Status: Completed
• Trial end date: 2007-11-01
• Target enrollment: 0
• Participant gender: Male

Summary

Does caffeine reduce rosuvastatin induced protection against ischemia reperfusion injury?

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Radboud University
• Treatments: Caffeine; Rosuvastatin Calcium

Criteria

Inclusion Criteria:

• Male

• age between 18-50 yrs

• signed informed consent

Exclusion Criteria:

• Cardiovascular disease

• Hypertension (systole > 140 mmHg, diastole > 90 mmHg)

• Hypercholesterolemia (fasting total cholesterol > 6,0 mmol/l)

• Drug abuse

• Concomitant medication use

• Inability to perform the ischemic isometric muscle contraction

• Diabetes Mellitus (fasting glucose > 7.0 mmol/L or random glucose > 11.0 mmol/L)

• Alanine-Amino-Transferase (ALAT) >90U/L (more than twice the upper level of the normal range)

• Creatinine Kinase (CK) >340U/L (more than twice the upper level of the normal range)

• Participation in any trial concerning medicinal products during the last 60 days prior to this study.

• Participation in clinical trial involving