Does Deep Neuromuscular Blockade Improve Operating Conditions During Total Hip Replacements?
Status:
Completed
Trial end date:
2018-05-01
Target enrollment:
Participant gender:
Summary
During many surgeries, increased muscle tension makes it harder for the surgeon to expose the
site of surgery and work within the incision. Neuromuscular blockade (NMB) drugs such as
Vecuronium bind to neurotransmitter (acetyl choline) receptors at the neuromuscular junction,
blocking their action and producing muscle relaxation. This muscle relaxation allows easier
retraction of muscle tissues and manipulation of structures in the wound. Improved surgical
conditions are likely to result in improved patient outcomes. While increased depths of NMB
have been shown to optimize surgical conditions during intra-abdominal and retroperitoneal
procedures, the impact of NMB depth has not been reported for orthopedic surgeries.1 To
address this, we propose to study the effect of NMB depth on surgical conditions during total
hip replacement (THR).
Phase:
Phase 4
Details
Lead Sponsor:
Craig Curry
Collaborators:
Maine Medical Center MaineHealth Spectrum Medical Group Anesthesiology