Does Fluoxetine Have an Effect on the CNS CRF Systems in Women Abused in Childhood?
Status:
Completed
Trial end date:
2007-11-01
Target enrollment:
Participant gender:
Summary
The primary objective of this project is to determine whether treatment with the SSRI,
fluoxetine versus placebo reverses alterations in the central CRF system induced by early
life stress experiences (i.e. childhood sexual and/or physical abuse) in cases with and
without major depression. We also evaluate whether neuroendocrine changes after SSRI
treatment correlate with clinical improvement.