Does Human Skeletal Muscle Possess an Epigenetic Memory of Testosterone?
Status:
Not yet recruiting
Trial end date:
2025-07-30
Target enrollment:
Participant gender:
Summary
This project's primary aim of this double-blinded, randomised, placebo-controlled trial is to
investigate whether short-term testosterone administration +/- resistance exercise training
induces a muscle memory response that can lead to longer-lasting benefits in aged human
skeletal muscle.
The investigators will provide older men with the anabolic hormone, testosterone or placebo,
with or without resistance training, followed by a period of testosterone abstinence and
detraining, followed by a subsequent repeated period of resistance training (retraining).
This will help determine if earlier encounters with short-term testosterone administration
can be "remembered" and if adaptation to later retraining can be enhanced as a consequence of
encountering testosterone earlier.