Does IV Acetaminophen Reduce Opioid Requirement in Pediatric Patients With Acute Sickle Cell Crises?

• Status: Completed
• Trial end date: 2020-02-20
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether IV acetaminophen can decrease the need for subsequent opioid administration in the acute management of sickle cell crisis pain in the pediatric emergency room.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Newark Beth Israel Medical Center
• Treatments: Acetaminophen; Analgesics, Opioid

Criteria

Inclusion Criteria:

• Any patient age 4-16 years with sickle cell disease who presents the Pediatric ER with acute sickle cell pain crisis with a pain of 6/10 or higher

Exclusion Criteria:

• Patient with fever (38C or 100.4F)

• Patient less than age 4 years

• Patient greater than age 16 years

• Patient with hypersensitivity/allergy to either morphine, NSAIDs, or acetaminophen

• Patient received acetaminophen within the past 4 hours

• Patient with known liver disease or renal disease

• Patient not requiring IV morphine (pain score 5/10 or less)

• Patient enrolled in the study within the past 72 hours