Does Oral Propranolol Accelerate Labor Induction/Augmentation With Oxytocin in Nulliparous Women in Abakaliki?

• Status: Completed
• Trial end date: 2021-04-30
• Target enrollment: 0
• Participant gender: Female

Summary

Labour is usually physiologic, spontaneous and progressive, but occasionally, there may be the need for induction or augmentation of labour especially in nulliparous women, who are at increased risk of dysfunctional labour. Oxytocin traditionally has been used for induction and augmentation of labour however prolonged labour continued to occur with attendant sequelae. Newer agents like propranolol, with minimal to no maternal and fetal adverse effects in labour have been shown to decreases the duration of labour when used in synergy with oxytocin. However, the paucity of information on the use of propranolol in labour.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Darlington-Peter Chibuzor Ugoji
• Treatments: Oxytocin; Propranolol

Criteria

Inclusion Criteria:

1. Nulliparous women selected for induction or augmentation of labour

2. Term pregnancy selected for induction or augmentation of labour

3. Normal singleton pregnancies with cephalic presenting foetuses.

4. Those who gave their consent.

Exclusion Criteria:

1. Co-existing medical illnesses such as diabetes mellitus, cardiac disease, haemoglobinopathies, renal diseases, hypertensive disease, Bronchial asthma,

2. Women currently taking Propranolol or a chronic beta-blocker use

3. Contraindications to labour or vaginal delivery

4. Multiple gestations

5. Preterm labour

6. Chorioamnionitis

7. Known fetal anomalies

8. Abnormal fetal presentation.

9. Antepartum haemorrhage.

10. Contraindication to induction and augmentation of labour

11. Multi-party

12. Known allergy to propranolol