Does Oral Sildenafil (Viagra) Decrease Mean Pulmonary Artery Pressure After Cardiac Surgery?
Status:
Completed
Trial end date:
2009-05-01
Target enrollment:
Participant gender:
Summary
Post-operative pulmonary hypertension is a risk factor for right ventricular failure and an
increasing cause of morbidity and mortality in patients undergoing high-risk cardiac surgery.
Several treatments have been used to treat and reduce post operative pulmonary hypertension.
Unfortunately none of these treatments are approved for use in this condition and only one
(inhaled nitric oxide) is specific enough to pulmonary hypertension to not cause dangerous
low blood pressure in the rest of the body. Sadly, inhaled nitric oxide is difficult and
expensive to use, and can cause lung damage. Sildenafil citrate is quite specific to the lung
vessels, is easy to administer and does not easily cause low blood pressure in other areas of
the body. We hypothesize that oral sildenafil 12.5mg will decrease the baseline (pre-dose)
mPAP by at least 20% compared with a placebo.
Phase:
Phase 2
Details
Lead Sponsor:
St. Michael's Hospital, Toronto Unity Health Toronto