Does Perineural Clonidine Prolong Duration of a Nerve Block?

• Status: Completed
• Trial end date: 2015-06-01
• Target enrollment: 0
• Participant gender: Male

Summary

The aim of this trial is to investigate if clonidine prolongs the duration of an adductor canal block. By using healthy volunteers the investigators can perform a bilateral adductor canal block and thereby control for a systemic effect to clarify if the effect is actually peripheral or systemic. The investigators hypothesis is that clonidine/dexmedetomidine as an adjunct to a local anaesthetic prolongs the duration of a peripheral nerve block by a peripheral mechanism.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Zealand University Hospital
• Treatments: Clonidine; Ropivacaine

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists class 1

• Body Mass Index 18-30

Exclusion Criteria:

• Allergy to study medication

• Earlier trauma or surgery to lower limb

• Diabetes Mellitus

• Alcohol or drug abuse

• Daily intake of opioids or steroids last 4 weeks

• Daily intake of any analgesics last 48 hours Heart block Sick sinus node.