Does Postoperative Gabapentin Reduce Pain, Opioid Consumption and Anxiety and Have a Positive Effect on Health Related Quality of Life After Radical Prostatectomy?

• Status: Completed
• Trial end date: 2010-01-01
• Target enrollment: 0
• Participant gender: Male

Summary

The Acute Pain Service (APS) at Sunnybrook has been using Gabapentin 200 mg three times a day (TID) resulting in anecdotal benefits in terms of analgesia and opioid sparing effects. Higher doses of Gabapentin were associated with an increased incidence of sedation. The purpose of the study is to investigate if Gabapentin 200 mg given three times a day for 72 hours (9doses) results in a reduction in the total amount of opioid required after radical prostatectomy surgery as compared to placebo, and if analgesia is improved. This study will also examine the possible anxiety sparing effects and any health related quality of life (HRQL) changes, which may be a result of our perioperative use of gabapentin.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sunnybrook Health Sciences Centre
• Treatments: Analgesics, Opioid; Gabapentin; gamma-Aminobutyric Acid

Criteria

Inclusion Criteria:

• Undergoing radical prostatectomy

• Able to read and write english (assistance is allowed)

• Normal creatinine blood serum level

• No known allergies to study medications

Exclusion Criteria:

• Patients not providing informed consent

• Patients less than 18 years of age or greater than 75 years of age

• Known allergy to any of the medications being used

• History of drug or alcohol abuse

• Preoperative pain

• Patients unable or unwilling to use PCA

• Patients with impaired renal function (Creatinine >106)