Does Preoperative Caldolor Decrease the Requirement for Postoperative Narcotics
Status:
Unknown status
Trial end date:
2015-03-01
Target enrollment:
Participant gender:
Summary
Caldolor® is an intravenous (IV) formulation of ibuprofen encompassing analgesic,
anti-inflammatory and antipyretic (anti-fever) properties. Caldolor® is the first IV
antipyretic approved by the US Food and Drug Administration (FDA), providing an alternate
route for administration of ibuprofen when the oral route is not preferable. Recent studies
have reported that Caldolor® decreases morphine use and pain at rest and with movement
compared to patients not receiving this drug.
The hypothesis of the proposed study is that a single dose of Caldolor® 800 mg given 30
minutes preoperatively for patients undergoing laparoscopic or open inguinal and/or umbilical
hernia repair will result in a >20% decrease in postoperative narcotic use within the first
24 hours and at 7 days, and decreased VAS Pain Score at 2 hours, 1 day, 3 days and 7 days
after surgery. The use of less postoperative narcotics has been associated with a faster
return of normal bowel function and resumption of normal ambulatory status thus resulting in
improved general well being for the patient.