Overview

Does Sildenafil Protect Against Pulmonary Related Complications Following Cardiopulmonary Bypass?

Status:
Unknown status

Trial end date:
1969-12-31

Target enrollment:
0

Participant gender:
All

Summary

Does pre-operative administration of Sildenafil (Viagra, Pfizer) reduce the lung injury associated with cardiopulmonary bypass in children undergoing corrective surgical repair of congenital heart disease.

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

NHS Greater Glasgow Yorkhill Division

Treatments:

Citric Acid
Sildenafil Citrate

Criteria

Inclusion Criteria:

Paediatric patients undergoing open heart surgery utilising cardiopulmonary bypass to
correct acyanotic congenital heart disease.

Age > 3 months Parents that show a good understanding of their child's condition and are
happy for their child to participate in the study.

Exclusion Criteria:

Patients with known organ dysfunction prior to surgery (pulmonary, renal or hepatic)
Communication barrier resulting in poor basic comprehension of the proposed study (e.g.
language barrier) Patients with cyanotic heart disease Patients undergoing heart surgery
without the use of cardiopulmonary bypass Patients who do not tolerate oral Sildenafil
(e.g. Vomiting) or whose surgery is subsequently cancelled.