Does Sleep Quality Change After Switch From Wellbutrin SR to Wellbutrin XL in Patients With Major Depressive Disorder?

• Status: Completed
• Trial end date: 2010-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Wellbutrin (bupropion) is an effective antidepressant (Thase, M 2005). It exists in instant release (IR), sustained release (SR) and extended release (XL) forms. The IR formulation was never approved for use in Canada. The XL formulation allows for once daily dosing.

Wellbutrin is both a norepinephrine and dopamine reuptake inhibitor, and as such increases the synaptic concentration of both neurotransmitters. This adds to its positive effects on cognition, apathy, tiredness and executive functioning. The increased activation may be also responsible for some of its side effects such as initial insomnia and reduced sleep efficiency, especially when taken at night.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Queen's University
• Treatments: Bupropion

Criteria

Inclusion Criteria:

1. Signed Patient Informed Consent;

2. Patients with Major Depressive Disorders (DSM-IV-TR - criteria used);

3. Out-patients;

4. Males or females over 18 years of age;

5. Patients currently using Wellbutrin SR.

Exclusion Criteria:

1. Bipolar Disorder patients;

2. Actively suicidal patients;

3. Schizophrenia, Schizoaffective or other Psychotic Disorder;

4. Pregnant women, as by pregnancy test at the beginning of the study;

5. Women in childbearing age, refusing to use appropriate contraception, or breastfeeding mothers;

6. Patients with known hypersensitivity to bupropion;

7. Patients with severe or unstable medical conditions, which in the opinion of the investigator would interfere with their progress or safety;

8. ECT or TMS treatments within the last three months;

9. Patients who did not respond to previous treatment with bupropion;

10. Patients with history of seizure disorder;

11. Patients with history of eating disorders (e.g. bulimia, anorexia nervosa);

12. Patients using sleep aiding medication (Benzodiazepines, barbiturates).