Does Topiramate Adjust the Excitability of the Brain in Migraine Sufferers?
Status:
Unknown status
Trial end date:
2006-08-01
Target enrollment:
Participant gender:
Summary
The purpose of the study is to determine by the use of non-invasive magnetic stimulation if
the medication Topiramate adjusts the excitability of the migraine sufferer's brain.
Previous studies have shown the migraine sufferer's brain is more excitable. The magnetic
stimulation device has given us a way to look at excitability and to see if it changes at the
same time that a headache diary shows if the pattern or severity of headaches changes with
the administration of the drug Topiramate.
It is expected that as migraine sufferers have fewer headaches with topiramate the testing
with magnetic stimulation will show that their brains are less excitable and that if the
topiramate does not change the character of headaches then the pattern of excitabilty would
not change from the baseline test before medication is started.