Does Tranexamic Acid Decrease Blood Loss in Pediatric Idiopathic Scoliosis Surgery?
Status:
Completed
Trial end date:
2016-05-01
Target enrollment:
Participant gender:
Summary
Adolescent idiopathic scoliosis surgery is an extensive procedure associated with significant
blood loss frequently requiring the transfusion of blood. Tranexamic acid (TXA) is a
synthetic antifibrinolytic (prevents breakdown of the blood clot) that has been used to
extensively reduce transfusion in pediatric major surgery, including cardiac, craniofacial
and orthopedic surgery. In this prospective randomized double-blinded study, the
investigators wish to evaluate the hypothesis that TXA is more effective than standard of
care at decreasing blood loss and blood transfusion perioperatively in children and
adolescents undergoing idiopathic scoliosis surgery.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
Boston Children's Hospital Boston Children’s Hospital