Does Tranexamic Acid Improve Visualization During Arthroscopic Rotator Cuff Repair

• Status: Recruiting
• Trial end date: 2022-04-01
• Target enrollment: 0
• Participant gender: All

Summary

This clinical trial examines whether intravenous preoperative administration of tranexamic acid (TXA) before arthroscopic rotator cuff repair (ARCR) can improve arthroscopic visualization during the procedure.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Saskatchewan
• Treatments: Tranexamic Acid

Criteria

Inclusion Criteria:

• Age 18-100

• Male and Female

• Patient able to read and understand consent form

• Non-traumatic, simple small or medium sized rotator cuff tear as defined by pre-operative MRI

• Booked to operating room for elective rotator cuff repair

• Beach chair positioning

Exclusion Criteria:

• Patient refusal to participate

• Massive rotator cuff tear

• Acute traumatic rotator cuff tear

• Known coagulopathy

• Patients with a history or risk of thromboembolism

• Known hypersensitivity to tranexamic acid

• Patient unable to be off anti-coagulant medication for long enough to counter effects

• Patient has a clinic systolic blood pressure > 150mmHg

• Lateral positioning

• Requirement or insistence by patient or anesthesiologist on regional block

• Patients who have smoked nicotine products within the last year

• The presence of other inflammatory conditions (calcific tendonitis, rheumatoid arthritis, etc.)

• The presence of active thromboembolic disease, such as deep vein thrombosis, pulmonary embolism, and cerebral thrombosis

• Patient has a seizure disorder

• Patients on medications identified as having drug-drug interactions (hormonal contraceptive, hydrochlorothiazide, desmopressin, sulbactam-ampicilllin, carbazochrome, ranitidine, or nitroglycerine

• Patient is pregnant

• Patients with history of subarachnoid hemorrhage

• Patients with renal insufficiency

• Patients with acquired disturbances of color vision