Does Type of Anesthesia Influence Inflammation Change After Breast Surgery?
Status:
Unknown status
Trial end date:
2021-11-01
Target enrollment:
Participant gender:
Summary
The Neutrophil to Lymphocyte Ratio (NLR) is a frequently used biomarker of the systemic
inflammatory response and is considered one of the most sensitive markers of inflammation.
Many studies have documented the association between the use of opioid drugs in the acute
phase -as it can be considered the use during general anesthesia- and the increase of the NLR
value. Such increase could determine a temporary phase of immunodepression in the immediate
post operative period with consequent increase of the inflammatory state.
This study intends to assess whether different anesthetic techniques can be associated with
different variations of the intra-patient NLR value between pre- and post-surgery. Patient
will be randomized to receive either local regional anesthesia protocols with thoracic wall
blocks (PEC I and serratus plane block) associated with opioid-free general anesthesia (PECS
+ Opioid-free GA) or general anesthesia.