Does a Perioperative Course of Gabapentin Improve Analgesia After Cesarean Delivery?
Status:
Completed
Trial end date:
2014-02-01
Target enrollment:
Participant gender:
Summary
Gabapentin has been very effective at treating pain after knee and hip operations,
hysterectomies, and many other types of operations. A previous study at the investigators'
hospital found that a single pre-operative dose of 600mg gabapentin produced a significant
reduction in pain after cesarean section. However, 19% of patients complained of sedation. A
subsequent study at the same institution looked to see if lowering the dose to 300mg would
decrease pain scores whilst reducing the sedative side-effect seen in the first trial. The
results were inconclusive but it provided valuable information to guide the design of this
study.
The purpose of this study is to see whether a preoperative dose of gabapentin, followed by a
48 hour low-dose course will produce improvement in pain scores. This study will compare the
efficacy of a peri-operative course of gabapentin (600mg one hour before the operation and
200mg every 8 hours for 2 days post-operatively) and a similar course of placebo in women
undergoing Cesarean section. The investigators' hypothesis is that a course of gabapentin
will result in decreased pain scores and increased satisfaction.
Phase:
N/A
Details
Lead Sponsor:
Samuel Lunenfeld Research Institute, Mount Sinai Hospital