Dolutegravir Interactions With Artemisinin-based Combination Therapies
Status:
Completed
Trial end date:
2016-09-01
Target enrollment:
Participant gender:
Summary
Malaria and HIV are found in the same regions of the world and developing countries are most
affected by both diseases. For malaria, new drugs have been introduced called ACTs. These
drugs are effective against malaria but little is known about how the levels of these drugs
in blood relate to how effective these drugs are. For HIV, a new drug has been developed
called dolutegravir which has potential to be widely used in developing countries. This
proposal will explore how dolutegravir affects the drug levels of these antimalarial drugs
and vice versa. In total, 46 healthy volunteers will participate in this study.