The purpose of this study is to assess the risk of serious cardiac events, specifically
ventricular tachyarrhythmia and sudden cardiac death (VT/SCD), associated with the use of
domperidone in a population of patients with Parkinson's disease. The hypothesis for this
study is that the risk of VT/SCD will be higher among domperidone users, especially at a
higher dose.
The investigators will conduct a retrospective population-based cohort study using health
care databases in eight jurisdictions in Canada and the UK. The study cohort will be defined
by the initiation of a new antiparkinsonian drug or a new diagnosis of Parkinson's disease.
The results from the separate sites will be combined by meta-analysis to provide an overall
assessment of the risk of VT/SCD in users of domperidone.
Details
Lead Sponsor:
Canadian Network for Observational Drug Effect Studies, CNODES
Collaborators:
Canadian Institutes of Health Research (CIHR) Drug Safety and Effectiveness Network, Canada