Donepezil Prevents Urinary Retention After Extensive Total Hysterectomy

• Status: Recruiting
• Trial end date: 2023-07-15
• Target enrollment: 0
• Participant gender: Female

Summary

Patients were randomly divided into experimental group and control group. The control group received routine postoperative treatment, while the experimental group took donepezil 5mg orally before going to bed every night from the first day after surgery. The catheter was removed and residual urine was measured in both groups 14 days after surgery, the catheter was successfully removed when the residual urine was less than 100ml. After 14 days, the patient was returned to the hospital for residual urine test, and the residual urine was repeated until the residual urine volume was less than or equal to 100ml. The incidence of postoperative urinary retention and adverse drug reactions were compared between the two groups.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
• Treatments: Donepezil

Criteria

Inclusion Criteria:

1. Age 18-80 years

2. Patients who meet the diagnostic criteria of cervical cancer in the Guidelines for the Diagnosis and Treatment of Cervical Cancer (the Fourth Edition) and have been diagnosed by cervical biopsy or colposcopy

3. Patients with surgical indications undergoing extensive abdominal total hysterectomy

4. The person who signed the informed consent.

Exclusion Criteria:

1. Allergic reaction to donepezil hydrochloride, piperidine derivatives or excipients in preparations

2. Patients with "sick sinus syndrome" or other supraventricular heart conduction diseases

3. Accompanied by serious liver, kidney and other organ dysfunction, serious infectious diseases

4. Patients with a history of mental illness and communication disorders

5. At the time of inclusion, patients with urinary tract infection had a history of urinary tract diseases (stones, congenital malformations, etc.)

6. Patients with intraoperative injury of urinary system, or postoperative ureteral fistula and vesicovaginal fistula.