Donepezil in Preventing Delirium in Hospitalized Elderly

• Status: Completed
• Trial end date: 2007-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to explore the efficacy of a perioperative daily dose of Donepezil (a cholinergic enhancer) in reducing the incidence and severity of delirium.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Indiana University Health
• Treatments: Donepezil

Criteria

Inclusion Criteria:

• Community-dwelling individuals aged 65 or older

• Admitted to Methodist Hospital for surgical repair of hip fracture

• No evidence of delirium at admission to hospital

• MMSE total score below 24 points after adjustment for education and age

• Consent to participate in the study

Exclusion Criteria:

• Severely demented as defined by MMSE score below 10

• Metastatic cancer or other comorbid illnesses likely to reduce life expectancy to under 6 months

• Multiple trauma or pathological fractures

• Aphasic, legally blind, or deaf

• Use of Donepezil or other cholinesterase inhibitors within one month prior to surgery

• Allergy to Donepezil