Donor Peripheral Stem Cell Transplant, Fludarabine, and Busulfan in Treating Patients With Hematologic Cancers
Status:
Completed
Trial end date:
2013-11-01
Target enrollment:
Participant gender:
Summary
Giving chemotherapy drugs, such as fludarabine and busulfan, before a donor peripheral stem
cell transplant helps stop the growth of cancer cells. It also stops the patient's immune
system from rejecting the donor's stem cells. The donated stem cells may replace the
patient's immune cells and help destroy any remaining cancer cells (graft-versus-tumor
effect). Sometimes the transplanted cells from a donor can also make an immune response
against the body's normal cells. Giving cyclosporine and mycophenolate mofetil before and
after the transplant may stop this from happening.
PURPOSE: This phase II trial is studying the side effects of giving donor peripheral stem
cell transplant together with fludarabine and busulfan and to see how well it works in
treating patients with hematologic cancers.