Donor Regulatory T Cells Infusion in Patients With Chronic Graft-versus-host Disease (GVHD)
Status:
Recruiting
Trial end date:
2022-12-01
Target enrollment:
Participant gender:
Summary
The immune system has offensive and defensive capacities. In bone marrow transplantation,
offensive cells in the donor grafts may attack host's organs, leading to a complication known
as Graft versus Host Disease (GVDH). At present, patients receive steroid treatment to combat
this tricky situation. Nevertheless, some patients do not respond to this therapy. Recently,
it has been shown that immune system cells having defensive capacities can help in preventing
the occurrence of a GVDH.
This study aims to evaluate if these protective cells together with a non-standard
immunosuppressor can improve the clinical condition and suppress the activity of the
offensive cells in the graft.