Donor Stem Cell Transplant, Pentostatin, and Total-Body Irradiation in Treating Patients With Hematological Cancer
Status:
Withdrawn
Trial end date:
2010-02-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Giving low doses of chemotherapy and total-body irradiation before a donor
peripheral blood stem cell transplant helps stop the growth of cancer cells. It may also stop
the patient's immune system from rejecting the donor's stem cells. The donated stem cells may
replace the patient's immune cells and help destroy any remaining cancer cells
(graft-versus-tumor effect). Sometimes the transplanted cells from a donor can also make an
immune response against the body's normal cells. Removing the T cells from the donor cells
before transplant and giving cyclosporine and mycophenolate mofetil after transplant may stop
this from happening.
PURPOSE: This phase I/II trial is studying the side effects of giving a donor stem cell
transplant after pentostatin and total-body irradiation and to see how well it works in
treating patients with hematological cancer.