Dopaminergic, Functional, Structural, and Cognitive Disturbances in First-episode Schizophrenia
Status:
Completed
Trial end date:
2010-09-01
Target enrollment:
Participant gender:
Summary
We wanted to compare dopamine D2 receptor activity, brain structure, brain function, sensory
gating and cognition in neuroleptic-naive schizophrenic patients and matched healthy
controls. Additionally, we wanted to examine the effects of 3 months of treatment with either
low doses of a typical or an atypical antipsychotic compound on the same functions. The
hypotheses were that schizophrenic patients suffered from disturbances in brain function and
structure, information processing, and extrastriatal D2 receptor activity, and that these
disturbances would be related to each other and to psychopathology. Additionally, we expected
the atypical compound to have an effect on some of the disturbances in information
processing, and that the atypical compound - in contrast to the typical drug - would show
extrastriatal over striatal selectivity.
Phase:
N/A
Details
Lead Sponsor:
Birte Glenthoj
Collaborators:
Copenhagen Hospital Corporation Glostrup University Hospital, Copenhagen Hvidovre University Hospital Janssen-Cilag Ltd. Rigshospitalet, Denmark The Danish Medical Research Council The Novo Nordic Foundation University of Copenhagen