Dose Escalation Phase I/II Study of Lovastatin With High-Dose Cytarabine for Refractory or Relapsed AML
Status:
Terminated
Trial end date:
2013-06-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to test the safety and effectiveness of combining a drug known
as Lovastatin to the chemotherapy drug cytarabine. Lovastatin is currently used to lower
blood cholesterol levels and lab data suggests that it increases the anti-leukemia activity
of cytarabine. This research is being done because high doses of cytarabine induce remissions
in only about 25% of patients with acute myeloid leukemia.