Dose-Escalation Study of Intensity-Modulated Radiotherapy(IMRT)in Patients With Unresectable Pancreatic Cancer
Status:
Completed
Trial end date:
2014-10-01
Target enrollment:
Participant gender:
Summary
This is a research study for pancreatic cancer. One way of improving the results of current
standard treatments is to try new approaches. This study will examine the use of a more
advanced radiation therapy technique, called intensity modulated radiation therapy (IMRT),
with chemotherapy. All subjects on this study will be treated with gemcitabine. This
chemotherapy agent has been used for patients with pancreatic cancer. The researchers have
already done studies using radiation therapy and gemcitabine. They want to build on the
information they have from this previous research. The researchers want to find the best dose
of IMRT that can be given at the same time that patients are receiving gemcitabine. To do
this, they will vary the total dose of radiation received by patients on this study based on
the information they have available from previously treated patients. The goal of the
research is to identify the highest dose of IMRT that can be given at the same time as the
chemotherapy without causing severe side effects.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
University of Michigan Cancer Center University of Michigan Rogel Cancer Center