Dose Escalation Trial of Tefinostat for Cancer Associated Inflamation in Hepatocellular Carcinoma (HCC)
Status:
Unknown status
Trial end date:
2018-12-01
Target enrollment:
Participant gender:
Summary
This study is being carried out to assess the best dose of a new drug, called tefinostat, in
treating liver cancer.
Tefinostat is a new drug that blocks enzymes called histone deacetylases (pronounced
dee-as-et-isle-azes). Cells need these enzymes to grow and divide. Blocking them may stop
cancer growing. Drugs that block these enzymes are called histone deacetylase inhibitors or
'HDAC inhibitors'.
Tefinostat has never been given to patients with liver cancer before so it isn't known which
dose is best at treating liver cancer. To find this out the study will be testing one dose
and if that is safe, then test a higher dose and so on.
The aim of this study is to find the best dose of tefinostat without causing side effects.
The study will be looking closely at any side effects patients might experience from this
treatment.