Dose Finding Study for Retarded Phosphatidylcholine in Pancolitis
Status:
Completed
Trial end date:
2006-03-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to find the optimal dose of retarded release Phosphatidylcholine
in the most severe form of ulcerative colitis.
The hypothesis is that ulcerative colitis (UC) is caused by a barrier dysfunction of the
colonic mucus layer. The background of the study is the finding, that the phosphatidylcholine
(PC) content of the colonic mucus is strongly reduced in UC compared to healthy controls and
patients with Crohn´s disease. The content was meuasured in non-inflamed areas of the colon
in UC. Thus, we evaluate whether a substitution of colonic PC is an effective method.