Dose Response Study of Dexmedetomidine in Orthopaedic Spine Surgery Patients

• Status: Completed
• Trial end date: 2020-03-01
• Target enrollment: 0
• Participant gender: All

Summary

To study the multimodal protocol combining adjunct dexmedetomidine with oxycodone in intravenous patient-controlled analgesia bolus dosing and effects in patients scheduled for posterolateral lumbar spine fusion with bilateral transpedicular screw instrumentation.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Turku University Hospital
• Collaborators: Helsinki University; University of Helsinki
• Treatments: Dexmedetomidine; Oxycodone

Criteria

Inclusion Criteria:

• Scheduled for elective posterolateral lumbar spine fusion with bilateral transpedicular screw instrumentation under general anaesthesia.

• Written informed consent from the participating subject

Exclusion Criteria:

• A previous history of intolerance to the study drug or related compounds and additives

• Concomitant drug therapy with oxycodone or buprenorphine.

• History of ischemic heart disease or conduction disturbance

• BMI > 35

• Existing significant haematological, endocrine, metabolic or gastrointestinal disease

• History of alcoholism, drug abuse, psychological or other emotional problems that are likely to invalidate informed consent

• Allergy to dexmedetomidine or oxycodone

• Blood loss exceeding 1500 ml during operation