Overview

Dose Response of Ketorolac in Knee Arthroscopy

Status:
Completed

Trial end date:
2016-12-15

Target enrollment:
0

Participant gender:
All

Summary

Ketorolac is administered as current practice to the majority of patients undergoing knee arthroscopy, the appropriate dose of ketorolac to be administered has not been evaluated.

Phase:

N/A

Accepts Healthy Volunteers?

Accepts Healthy Volunteers

Details

Lead Sponsor:

Medical University of South Carolina

Treatments:

Ketorolac
Ketorolac Tromethamine

Criteria

Population: Patients scheduled for outpatient knee arthroscopy under general anesthesia
with ASA physical status I-III ages 18-65 years old. All subjects will receive informed
consent. Subjects will not be eligible to participate if they cannot provide informed
consent. Non-English speaking patients will not be included due to the limited time and
availability of translators.

Inclusion Criteria:

1. Ability to consent and desire to participate in study

2. Outpatient knee arthroscopy with Dr. C. David Geier

3. ASA physical status I-III

4. 18-65 years old

5. Over 50 kg (110 pounds)

6. General anesthesia

Exclusion Criteria

1. Any contraindication to receiving a non-steroidal antiinflammatory medication
(including but not limited to allergy to any non-steroidal antiinflammatory
medications including aspirin; chronic renal insufficiency; history of gastric ulcers,
gastritis, peptic ulcers or gastrointestinal bleeding; severe volume depletion;
presence of cerebrovascular bleeding or high risk of bleeding)

2. Allergy to propofol, fentanyl or hydromorphone.

3. Any chronic painful conditions requiring opioid use for over the last 6 months

4. Emergency surgery

5. Altered mental status (not oriented to place, person or time)

6. Pregnant or lactating patients

7. Patient is taking non-steroidal antiinflammatory medications (including aspirin)1 at
home and took that medication on day of surgery.

8. Non-English speaking

9. Patient refusal to study

10. Patient refusal or not a candidate for general anesthesia with Laryngeal Mask Airway
(LMA)