Dose and Duration of Metronidazole and Amoxicillin for Treatment of Chronic Periodontitis

• Status: Active, not recruiting
• Trial end date: 2020-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study was to compare the clinical and microbiological outcomes of different dosages of metronidazole (MTZ) and of the duration of the systemic administration of MTZ and amoxicillin as adjunct to scaling and root planing (SRP) in the treatment of generalized chronic periodontitis (GChP).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Guarulhos
• Treatments: Amoxicillin; Metronidazole

Criteria

Inclusion Criteria:

• ≥30 years of age;

• at least 15 teeth (excluding third molars and teeth with advanced decay indicated for extraction)

• a minimum of 6 teeth with at least one site each with probing depth (PD) and clinical
• attachment level (CAL) ≥5 mm;

• at least 30% of the sites with PD and CAL ≥4 mm and bleeding on probing (BOP).

Exclusion Criteria:

• pregnancy

• breastfeeding

• current smoking and former smoking within the past 5 years;

• systemic diseases that could affect the progression of periodontitis (e.g. diabetes, immunological disorders, osteoporosis);

• scaling and root planing an in the previous 12 months;

• antibiotic therapy in the previous 6 months;

• long-term intake of anti-inflammatory medications;

• need for antibiotic pre-medication for routine dental therapy;

• allergy to metronidazole and/or amoxicillin.