Dose-response Curves Between Propofol and Intraoperative Electroencephalographic Patterns
Status:
Completed
Trial end date:
2020-02-26
Target enrollment:
Participant gender:
Summary
In the world, 230 million surgeries are performed per year and a significant part is
performed in patients over 65 years of age. These patients are more labile, especially from
the neurocognitive point of view with a high risk to develop neurocognitive complications,
such as postoperative delirium. Recent studies have linked this type of complication with an
overdose of general anesthetics during surgery. For this reason, in recent years, the use of
brain function monitors during the intraoperative period has been recommended to adapt the
dosage of the drugs to each patient and thus to avoid overdosing of general anesthetics.
However, to date, the available monitors that process the electroencephalographic signal are
not able to adequately discriminate gradual changes in anesthetic depth. Also, no systematic
studies have been performed that analyze changes that occur in the electroencephalogram (EEG)
signal secondary to increases in complications from general anesthetics. Thus, the
investigators design this study with the main aim to determine the changes in
electroencephalographic patterns induced by a stepped increase of propofol until the burst
suppression is reached.