Dose-response Curves Between Propofol and Intraoperative Electroencephalographic Patterns

• Status: Completed
• Trial end date: 2020-02-26
• Target enrollment: 0
• Participant gender: All

Summary

In the world, 230 million surgeries are performed per year and a significant part is performed in patients over 65 years of age. These patients are more labile, especially from the neurocognitive point of view with a high risk to develop neurocognitive complications, such as postoperative delirium. Recent studies have linked this type of complication with an overdose of general anesthetics during surgery. For this reason, in recent years, the use of brain function monitors during the intraoperative period has been recommended to adapt the dosage of the drugs to each patient and thus to avoid overdosing of general anesthetics. However, to date, the available monitors that process the electroencephalographic signal are not able to adequately discriminate gradual changes in anesthetic depth. Also, no systematic studies have been performed that analyze changes that occur in the electroencephalogram (EEG) signal secondary to increases in complications from general anesthetics. Thus, the investigators design this study with the main aim to determine the changes in electroencephalographic patterns induced by a stepped increase of propofol until the burst suppression is reached.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Chile
• Treatments: Propofol

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists (ASA) Physical Status 1 or 2

• Low-risk surgery

Exclusion Criteria:

• BMI > 35 kg/m2

• Benzodiazepines use

• Epilepsy

• Psychiatric disorder

• Kidney disease

• Liver disease

• Brain damage