Dosing of Methadone for Spine Surgery

• Status: Completed
• Trial end date: 2020-05-09
• Target enrollment: 0
• Participant gender: All

Summary

This study compares two methods of dosing methadone for complex spine cases

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Florida
• Treatments: Methadone

Criteria

Inclusion Criteria:

• Patients must consent to participate and sign the Institutional Review Board (IRB) approved informed consent prior to beginning any study specific procedures.

• Undergoing multiple thoracolumbar spine surgery with instrumentation and fusion

Exclusion Criteria:

• History of methadone use

• Morbid obesity with BMI>40 Kg/m2.

• Chronic renal failure with creatinine>2.0 mg/dL

• Liver failure as determined by cirrhosis or history of fulminant hepatic failure

• History of alcohol abuse

• History of drug abuse

• History of myocardial infarction or heart failure.

• Patients with American Society of Anesthesiologists (ASA) status IV or V