Double Blind Study of Hypertonic Saline vs Mannitol in the Management of Increased Intracranial Pressure (ICP).
Status:
Withdrawn
Trial end date:
2014-01-01
Target enrollment:
Participant gender:
Summary
The study goal is to compare the management of increased intra-cranial pressure (ICP) using
3% hypertonic saline vs. mannitol (given in same osmolar loads).
Primary hypothesis:
1. Hypertonic saline will be non-inferior to mannitol in decreasing elevated ICP.
Secondary hypotheses:
1. Hypertonic saline therapy will result with fewer complications than mannitol
2. ICP reduction duration will be longer using hypertonic saline when compared with
mannitol