Double Stimulation Followed by a Fresh Embryo Transfer

• Status: Recruiting
• Trial end date: 2022-10-01
• Target enrollment: 0
• Participant gender: Female

Summary

The major goal of controlled ovarian stimulation (COS) is to increase the number of oocytes harvested in order to result in the generation of a higher number of available embryos, extended embryo culture, embryo selection and finally providing higher cumulative live birth rates in infertile patients. Moreover, with the idea of the multiple waves of follicular production, we could start to take full advantage of the whole follicular cohort, and not only of the follicular wave.

In the context of low prognosis women such as women with poor ovarian response where, the success rates are very low due to the low number of oocytes retrieved and consequently of viable embryos), Dual stimulation may be of great value as a tool to improve outcomes.

The reported advantage of DuoStim is retrieved of more oocytes within a shorter time span, resulting in an increase in the probability of having transferable embryos increases, and theoretically reducing time to live birth as well as cycle cancellation.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fundación Santiago Dexeus Font
• Collaborator: Merck Sharp & Dohme Corp.

Criteria

Inclusion Criteria:

• Poor prognosis patients according to the POSEIDON group 3 & 4 (based on AMH)

• AMH <1.2

• age <40 years old

• BMI >18 and <35 kg/m2

• Body weight >50kg (in women <36 years old body weight >60kg)

Exclusion Criteria:

• Maternal age > 40 years

• History of untreated autoimmune, endocrine or metabolic disorders

• Previous ovarian cystectomy or oophorectomy

• Body weight <50kg (and body weight <60kg in women <36 years old)