Double-blind Trial of Mannitol Cream to Block the Effect of Capsaicin Cream
Status:
Completed
Trial end date:
2014-01-01
Target enrollment:
Participant gender:
Summary
Capsaicin is a TRPV1 (transient receptor potential vanilloid 1) agonist, causing pain upon
application. The investigators wish to determine whether mannitol blocks the effect of
capsaicin application. As both cream bases are identical and mannitol addition is the only
difference between the creams, if the mannitol cream is more effective in blocking the effect
of capsaicin on the TRPV1 (transient receptor potential vanilloid 1) receptor, the
investigators will have established that mannitol down-regulates or blocks the TRPV1
(transient receptor potential vanilloid 1) receptor.