Doxazosin Effects on ABPM in Hypertensive Patients With Diabetic Nephropathy

• Status: Completed
• Trial end date: 2007-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Few studies have reported the effect of alpha1-adrenergic antagonists on 24-h blood pressure and regulation of sympathetic nervous activity in hypertensive patients with diabetic nephropathy. Using ambulatory blood pressure monitoring devices equipped with spectral analysis of heart rate variability, we assess the effects of doxazosin on blood pressure in diabetic nephropathy patients and compare the results with those in patients with essential hypertension, patients with diabetes mellitus and patients with chronic nephropathy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yokohama City University Medical Center
• Treatments: Doxazosin

Criteria

Inclusion Criteria:

• Hypertensive patients with diabetes mellitus

• Hypertensive patients

• Hypertensive patients with renal disease

Exclusion Criteria:

• Cardiac, hematologic or hepatic disease

• Renal insufficiency (serum creatinine values> 2 mg/L)

• Hormone-induced hypertension

• Cerebral infarction or hemorrhage

• Other major diseases